| Autor: |
Win Hlaing Than, Gordon Chun-Kau Chan, Bonnie Ching-Ha Kwan, Ka-Bik Lai, Ronald Cheong-Kin Chan, Jeromy Yuen Chun Teoh, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Kai-Ming Chow, Phyllis Mei-Shan Cheng, Man-Ching Law, Philip Kam-Tao Li, Cheuk-Chun Szeto |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Kidney Medicine, Vol 5, Iss 3, Pp 100589- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0595 |
| DOI: |
10.1016/j.xkme.2022.100589 |
| Popis: |
Rationale & Objective: Cardiovascular disease is the major cause of mortality and morbidity in peritoneal dialysis (PD) patients. Adiponectin, a key adipokine, is related to obesity and insulin resistance. We determined the clinical and prognostic value of plasma adiponectin level and its adipose tissue messenger RNA (mRNA) expression in new PD patients. Study Design: Retrospective analysis of a prospective observational study. Setting & Participants: 152 new PD patients from a single center; 6 adults undergoing abdominal surgeries without kidney disease served as controls. Predictors: Plasma adiponectin level and its adipose tissue mRNA expression. Outcomes: Body build and composition, patient and technique survival. Analytical Approach: Adiponectin level and mRNA expression were grouped in quartiles for correlation analysis for body build and Cox regression for survival analysis. Results: The median plasma adiponectin level was 31.98 μg/mL (IQR, 16.81-49.49 μg/mL), and adiponectin mRNA expression in adipose tissue was 1.65 times higher than in controls (IQR, 0.98-2.63). There was a modest but statistically significant correlation between plasma adiponectin and its adipose tissue mRNA expression (r = 0.40, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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