| Autor: |
Sylwia Przybylska-Kuć, Maciej Zakrzewski, Andrzej Dybała, Paweł Kiciński, Grzegorz Dzida, Wojciech Myśliński, Andrzej Prystupa, Barbara Mosiewicz-Madejska, Jerzy Mosiewicz |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 14, Iss 9, p e0221255 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0221255 |
| Popis: |
ObjectivesAmyloid-β 1-40 (Aβ 1-40) and amyloid-β 1-42 (Aβ 1-42) are the proteins known to be involved in the pathogenesis of Alzheimer's disease (AD)-the most common cause of dementia in the elderly. Hypoxia is suspected to be one of conditions associated with Aβ plasma level increase. A common reason of hypoxia is obstructive sleep apnea (OSA), characterized by recurrent episodes of apnea.AimThe aim of the study was to evaluate plasma Aβ 1-40 and Aβ 1-42 concentrations in patients with OSA.MethodsPatients with suspected OSA (n = 112) underwent polygraphic examinations Patients with confirmed OSA (n = 81) showed apnea/hypopnea index greater than or equal to 5. Mild and moderate form of the disease was defined when AHI was 5-30 (n = 38, OSA+), severe-when AHI was >30 (n = 43, OSA++). Individuals with AHIResultsAβ 1-40 concentrations in OSA++ (191.1 pg/ml) group was significantly (pConclusionIn patients with severe OSA Aβ 1-40 plasma concentrations are significantly higher compared with OSA- and OSA+ and seem to be related to hypoxia severity, which may indicate increased risk of AD development in this group of patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
