Neonatal cystic fibrosis screening: Analysis and differences in immunoreactive trypsin levels in newborns with a positive screen

Autor: Marta Arrudi-Moreno, Ruth García-Romero, Pilar Samper-Villagrasa, María José Sánchez-Malo, Carlos Martin-de-Vicente
Jazyk: Spanish; Castilian
Rok vydání: 2021
Předmět:
Zdroj: Anales de Pediatría (English Edition), Vol 95, Iss 1, Pp 11-17 (2021)
Druh dokumentu: article
ISSN: 2341-2879
DOI: 10.1016/j.anpede.2020.04.022
Popis: Introduction: Neonatal cystic fibrosis (CF) screening has enabled the disease to be diagnosed early, and is a determining factor in the increase in survival of these patients. Its main disadvantage is its low specificity and elevated number of false positives. The aim of this study is to analyse the differences in immunoreactive trypsin (IRT) between the different groups of newborns (NB) with a positive neonatal screen depending on whether they were healthy, healthy carriers, affected by CF, or CFSPID (Cystic Fibrosis Screen Positive, Inconclusive Diagnosis). Material: Retrospective analytical study of the concentrations of IRT in NB with a positive neonatal screen for CF born in a tertiary hospital during an 8-year period. Results: A total of 790 NB with a positive neonatal screen for CF were analysed. Of these 86.3% were term, 53% girls, and 11.8% were admitted. The mean IRT value was 79.16 ng/mL (range 60–367). Significantly higher concentrations of IRT were found in those affected by CF compared to the other groups (P
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