Plasma Homocysteine Is Associated with Increased Oxidative Stress and Antioxidant Enzyme Activity in Welders

Autor: Hung-Hsin Liu, Tung-Sheng Shih, Hsin-Ru Huang, Shih-Chien Huang, Lien-Hsiung Lee, Yi-Chia Huang
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: The Scientific World Journal, Vol 2013 (2013)
Druh dokumentu: article
ISSN: 1537-744X
DOI: 10.1155/2013/370487
Popis: The purpose of this study was to examine the association of vitamin B6 status and plasma homocysteine with oxidative stress and antioxidant capacities in welders. Workers were divided into either the welding exposure group (n=57) or the nonexposure controls (n=42) based on whether they were employed as welders. There were no significant differences in vitamin B6 status and plasma homocysteine concentration between the welding exposure group and the nonexposure controls. The welding exposure group had significantly higher levels of oxidized low-density lipoprotein cholesterol and lower erythrocyte glutathione concentration and superoxide dismutase (SOD) activities when compared to nonexposure controls. Plasma pyridoxal 5′-phosphate concentration did not correlate with oxidative stress indicators or antioxidant capacities in either group. However, plasma homocysteine significantly correlated with total antioxidant capacity (TAC) (partial rs=-0.34, P
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