| Autor: |
Niraldo Paulino, Andreia Pires Dantas, Vassya Bankova, Daniela Taggliari Longhi, Amarilis Scremin, Solange Lisboa de Castro, João Batista Calixto |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Journal of Pharmacological Sciences, Vol 93, Iss 3, Pp 307-313 (2003) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/S1347-8613(19)32580-0 |
| Popis: |
ABSTRACT: Propolis is a bee product, which has long been used in folk medicine for the management of different diseases. In this study we evaluated the analgesic and anti-inflammatory effects of a standard ethanolic extract of Bulgarian propolis (Et-Blg) in mice and its in vitro effect on airway smooth muscle. Et-Blg inhibited acetic acid-induced abdominal contortions with an ID50 = 7.4 ± 0.7 mg · kg-1. In the formalin test, the extract caused a significant reduction in pain in mice treated with 100 mg · kg-1 Et-Blg during the neurogenic phase and for the inflammatory phase with all doses of the extract, with an ID50 = 2.5 ± 0.4 mg · kg-1. Et-Blg inhibited also the capsaicin-induced ear edema in mice; however, this extract was ineffective when assessed in the tail-flick and hot-plate thermal assays. The analgesic effect of Et-Blg was associated with the inhibition of inflammatory responses and not to a simple irritation of nervous terminals. In vitro, this extract inhibited the contraction of trachea smooth muscle induced by histamine (IC50 = 50 ± 5 μg · mL-1), capsaicin (IC50 = 26.8 ± 3 μg · mL-1), 80 mM KCl (IC50 = 27.8 ± 3 μg · mL-1), and carbachol (IC50 = 54 ± 2 μg · mL-1). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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