AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice

Autor: Madelene Ericsson, Pär Steneberg, Rakel Nyrén, Helena Edlund
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02837-0
Popis: Ericsson et al. show in aged mice that the panAMPK activator O304 prevents and reverts age-associated hyperinsulinemia and insulin resistance, as well as improving cardiac function and exercise capacity. O304 thus functions as an exercise mimetic and could therefore have a similar therapeutic potential in aged humans and improve quality of life.
Databáze: Directory of Open Access Journals