| Autor: |
Josephine M. Forbes, Selena Le Bagge, Samuel Righi, Amelia K. Fotheringham, Linda A. Gallo, Domenica A. McCarthy, Sherman Leung, Tracey Baskerville, Janelle Nisbett, Adam Morton, Stephanie Teasdale, Neisha D’Silva, Helen Barrett, Timothy Jones, Jennifer Couper, Kim Donaghue, Nicole Isbel, David W. Johnson, Leigh Donnellan, Permal Deo, Lisa K. Akison, Karen M. Moritz, Trisha O’Moore-Sullivan |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-88786-4 |
| Popis: |
Abstract To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/mol; diabetes duration 10.7 ± 5.2 years; BMI 24.5(5.3) kg/m2) and healthy controls (N = 299; 20.3 ± 1.8 years; M:F-83:116; FBG 5.2 ± 0.8 mmol/L; BMI 22.5(3.3) kg/m2) were recruited. Skin autofluorescence (sAF) and circulating AGEs were measured. In a subset of both groups, kidney function was estimated by GFRCKD-EPI CysC and uACR, and DKD risk defined by uACR tertiles. Youth with type 1 diabetes had higher sAF and BMI, and were taller than controls. For sAF, 13.6% of variance was explained by diabetes duration, height and BMI (P model = 1.5 × 10–12). In the sub-set examining kidney function, eGFR and sAF were higher in type 1 diabetes versus controls. eGFR and sAF predicted 24.5% of variance in DKD risk (P model = 2.2 × 10–9), which increased with diabetes duration (51%; P model |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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