Synthetic studies towards bottromycin

Autor: Stefanie Ackermann, Hans-Georg Lerchen, Dieter Häbich, Angelika Ullrich, Uli Kazmaier
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1652-1656 (2012)
Druh dokumentu: article
ISSN: 1860-5397
DOI: 10.3762/bjoc.8.189
Popis: Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.
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