Lateral gain is impaired in macular degeneration and can be targeted to restore vision in mice

Autor: M. Rizzi, K. Powell, M. R. Robinson, T. Matsuki, J. Hoke, R. N. Maswood, A. Georgiadis, M. Georgiou, P. R. Jones, C. Ripamonti, F. M. Nadal-Nicolás, M. Michaelides, G. S. Rubin, A. J. Smith, R. R. Ali
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-29666-x
Popis: Treatments to rescue vision are currently limited. Here, the authors identify a cone-driven gain control mechanism that reduces visual function beyond the atrophic area in humans. They also show that activating laterally projecting cells results improved vision in two mouse models of retinal degeneration.
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