Secuelas neuropsiquiátricas a largo plazo en la tuberculosis del sistema nervioso central en pacientes mexicanos
| Autor: | Hanna Martínez |
|---|---|
| Jazyk: | English<br />Spanish; Castilian |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Infectio, Vol 28, Iss 2, Pp 110-117 (2024) |
| Druh dokumentu: | article |
| ISSN: | 24223794 0123-9392 |
| DOI: | 10.22354/24223794.1177 |
| Popis: | Introduction: Central nervous system tuberculosis (CNS TB), the most serious form of TB, is usually associated with an intense neuroinflammatory response and severe sequels, and it is often accompanied by human immunodeficiency virus (HIV) coinfection. Few works have studied mental functioning sequels in this population. Objective: The aim of this study was to characterize long-term neuropsychiatric sequels in central nervous system tuberculosis (CNS TB) patients and CNS TB/Human Immunodeficiency Virus (HIV) co-infected patients, and to describe some associated factors.Methods: Retrospective cohort study in CNS TB patients admitted from 2008 to 2018 in a Mexican neurological center in which sociodemographic, clinical, neuroimaging, cognitive, and neuropsychiatric data were collected. Cognitive sequel data were obtained from a screening tool that has been standardized and normalized for the Hispanic population. Neuropsychiatric data were obtained from the Neuropsychiatric Inventory Questionnaire and from medical records.Results: A total of 86 subjects were included, 23 had CNSTB and HIV. The mean age was 40.4 years, and 23% of patients had a history of pulmonary TB. The main symptoms were headache, fever, and cranial nerve palsy. Executive functions, visuospatial, and memory impairment were the most common neurocognitive se-quels, while the most frequent neuropsychiatric sequels were depression, irritability, and anxiety. There was a correlation between immunity (CD4+ T cell count) and executive functions.Conclusions: This is the first report in Mexican patients evaluating long-term neurocognitive sequels in CNS TB. Some clinical and sociodemographic traits seem to be neuroprotective factors against long-term neuropsychiatric sequels. |
| Databáze: | Directory of Open Access Journals |
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