Low levels of serum testosterone in middle-aged men impact pathological features of prostate cancer

Autor: Elton Llukani, Benjamin F. Katz, Ilir Agalliu, Andrew Lightfoot, Sue-Jean S. Yu, Martin Kathrins, Ziho Lee, Yu-Kai Su, Kelly Monahan Agnew, Alice McGill, Daniel D. Eun, David I. Lee
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Prostate International, Vol 5, Iss 1, Pp 17-23 (2017)
Druh dokumentu: article
ISSN: 2287-8882
DOI: 10.1016/j.prnil.2016.12.003
Popis: Background: Serum testosterone deficiency increases with aging. Age is also a major risk factor for prostate cancer (PrCa) and PCa tumors are more frequently diagnosed among men >65 years old. We evaluated the relationship between preoperative serum testosterone and clinical/ pathological features of PrCa in middle-aged and elderly patients. Methods: A total of 605 PrCa patients who underwent robotic-assisted radical prostatectomy between September 2010 and January 2013 at the University of Pennsylvania, and who had serum testosterone levels measured using Elecsys Testosterone II Immunoassay were included in this IRB-approved protocol. Androgen deficiency was determined as serum free testosterone (FT)
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