DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels
| Autor: | Gregory T. Jones, Judith Marsman, Basharat Bhat, Victoria L. Phillips, Aniruddha Chatterjee, Euan J. Rodger, Michael J. A. Williams, André M. van Rij, Sally P. A. McCormick |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Epigenetics, Vol 15, Iss 9, Pp 949-958 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1559-2294 1559-2308 15592294 |
| DOI: | 10.1080/15592294.2020.1739797 |
| Popis: | Changes in whole blood DNA methylation levels at several CpG sites have been associated with circulating blood lipids, specifically high-density lipoprotein and triglycerides. This study performs a discovery and validation epigenome-wide association study (EWAS) for circulating lipoprotein(a) [Lp(a)], an independent risk factor for cardiovascular diseases. Whole-blood DNA methylation profiles were assessed in a cohort of 1020 elderly individuals using the Illumina EPIC array and independent validation in 359 elderly males using the Illumina 450 k array. Plasma Lp(a) was measured using an apolipoprotein(a)-size-independent ELISA. Epigenome-wide rank regression analysis identified and validated a single CpG site, cg17028067 located in intron 1 of the LPA gene, that was significantly associated with plasma Lp(a) levels after correction for multiple testing. Genotyping of the site identified a relatively uncommon SNP (rs76735376, MAF |
| Databáze: | Directory of Open Access Journals |
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