| Autor: |
Lakshmi Mundkur, Rupak Mukhopadhyay, Sonia Samson, Meenakshi Varma, Dnyaneswar Kale, Daxin Chen, Sneha Shivaprasad, Hemapriya Sivanandan, Vinod Soman, Xinjie Lu, Vijay V Kakkar |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 8, Iss 3, p e58364 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0058364 |
| Popis: |
Oral tolerance to auto antigens reduces the development of atherosclerosis in mouse models. However, the effect of immune tolerance to multiple self antigenic peptides in plaque progression and stabilization is not known. We studied the protective effect of mucosal tolerance to peptides from apolipoprotein B (ApoB; 661-680) and heat shock protein 60 (HSP60; 153-163), in combination with diet, in the prevention of atherosclerotic lesion progression and plaque stabilization in ApoB(tm25gy)LDLr(tm1Her) mice. We found that oral administration of five doses of a combination of ApoB and HSP60 peptides (20 µg/mice/dose) induced tolerance to both the peptides and reduced early plaque development by 39.9% better than the individual peptides (ApoB = 28.7%;HSP60 = 26.8%)(P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
