Myocyte necrosis is the basis for fibrosis in renovascular hypertensive rats
| Autor: | M.P. Okoshi, L.S. Matsubara, M. Franco, A.C. Cicogna, B.B. Matsubara |
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| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 30, Iss 9, Pp 1135-1144 (1997) |
| Druh dokumentu: | article |
| ISSN: | 1414-431X 0100-879X |
| DOI: | 10.1590/S0100-879X1997000900013 |
| Popis: | The pathogenesis of fibrosis and the functional features of pressure overload myocardial hypertrophy are still controversial. The objectives of the present study were to evaluate the function and morphology of the hypertrophied myocardium in renovascular hypertensive (RHT) rats. Male Wistar rats were sacrificed at week 4 (RHT4) and 8 (RHT8) after unilateral renal ischemia (Goldblatt II hypertension model). Normotensive rats were used as controls. Myocardial function was analyzed in isolated papillary muscle preparations, morphological features were defined by light microscopy, and myocardial hydroxyproline concentration (HOP) was determined by spectrophotometry. Renal artery clipping resulted in elevated systolic arterial pressure (RHT4: 178 ± 19 mmHg and RHT8: 194 ± 24 mmHg, P |
| Databáze: | Directory of Open Access Journals |
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