Individual response in patient’s effort and driving pressure to variations in assistance during pressure support ventilation

Autor: Mattia Docci, Emanuele Rezoagli, Maddalena Teggia-Droghi, Andrea Coppadoro, Matteo Pozzi, Alice Grassi, Isabella Bianchi, Giuseppe Foti, Giacomo Bellani
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Annals of Intensive Care, Vol 13, Iss 1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 2110-5820
DOI: 10.1186/s13613-023-01231-9
Popis: Abstract Background During Pressure Support Ventilation (PSV) an inspiratory hold allows to measure plateau pressure (Pplat), driving pressure (∆P), respiratory system compliance (Crs) and pressure-muscle-index (PMI), an index of inspiratory effort. This study aims [1] to assess systematically how patient’s effort (estimated with PMI), ∆P and tidal volume (Vt) change in response to variations in PSV and [2] to confirm the robustness of Crs measurement during PSV. Methods 18 patients recovering from acute respiratory failure and ventilated by PSV were cross-randomized to four steps of assistance above (+ 3 and + 6 cmH2O) and below (-3 and -6 cmH2O) clinically set PS. Inspiratory and expiratory holds were performed to measure Pplat, PMI, ∆P, Vt, Crs, P0.1 and occluded inspiratory airway pressure (Pocc). Electromyography of respiratory muscles was monitored noninvasively from body surface (sEMG). Results As PSV was decreased, Pplat (from 20.5 ± 3.3 cmH2O to 16.7 ± 2.9, P
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