Necrobiotic xanthogranuloma: A case report of successful treatment with intravenous immunoglobulins

Autor:	Julia K. Winkler, Holger A. Haenssle, Jochen Hoffmann, Ferdinand Toberer, Alexander H. Enk
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	granulomas histiocytes intravenous immunoglobulin therapy monoclonal gammopathy necrobiotic xanthogranuloma Dermatology RL1-803 Diseases of the genitourinary system. Urology RC870-923
Zdroj:	JEADV Clinical Practice, Vol 3, Iss 4, Pp 1248-1252 (2024)
Druh dokumentu:	article
ISSN:	2768-6566
DOI:	10.1002/jvc2.411
Popis:	Abstract Necrobiotic xanthogranuloma (NXG) is a rare non‐Langerhans cell histiocytosis associated with paraproteinemia. Skin lesions of NXG are difficult to treat and various therapies have been evaluated with inconsistent results. A therapeutic standard has not been established. We report on a patient severely affected by mutilating skin and ocular lesions as well as lung infiltrates of necrobiotic xanthogranuloma. After failure of several previous therapies including dapsone and adalimumab, lesions significantly improved during therapy with intravenous immunoglobulins (IVIg). IVIg are an effective treatment option to evaluate in NXG.
Databáze:	Directory of Open Access Journals
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