Spatial structure impacts adaptive therapy by shaping intra-tumoral competition

Autor: Maximilian A. R. Strobl, Jill Gallaher, Jeffrey West, Mark Robertson-Tessi, Philip K. Maini, Alexander R. A. Anderson
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Medicine, Vol 2, Iss 1, Pp 1-18 (2022)
Druh dokumentu: article
ISSN: 2730-664X
DOI: 10.1038/s43856-022-00110-x
Popis: Strobl et al. develop an agent-based spatial model of drug resistance in tumour cells under adaptive therapy. Using this model, they investigate how the tumour’s spatial architecture impacts intratumoural competitive dynamics of drug-sensitive vs. -resistant clones in response to therapy.
Databáze: Directory of Open Access Journals