| Autor: |
Marcelo Antonio Pascoal-Xavier, Anna Carolina Cançado Figueiredo, Luciana Inácia Gomes, Vanessa Peruhype-Magalhães, Carlos Eduardo Calzavara-Silva, Marcelo Azevedo Costa, Ilka Afonso Reis, Claudio Antônio Bonjardim, Erna Geessien Kroon, Jaquelline G de Oliveira, Paulo César Peregrino Ferreira |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 10, Iss 4, p e0123531 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0123531 |
| Popis: |
RAP1 (RAS proximate 1), a small GTP-binding protein of the RAS superfamily, is a putative oncogene that is highly expressed in several malignant cell lines and types of cancers, including some types of squamous cell carcinoma. However, the participation of RAP1 in cervical carcinogenesis is unknown. We conducted a cross-sectional study of paraffin-embedded cervical biopsies to determine the association of RAP1 with cervical intraepithelial neoplasia (CIN). Standard and quantitative immunohistochemistry assessment of RAP1 expression in fixed tissue was performed on 183 paraffin-embedded cervical biopsies that were classified as normal or non-dysplastic mucosa (NDM) (n = 33); CIN grade 1 (n = 84) and CIN grade 2/3 (n = 66). A gradual increase in RAP1 expression in NDM < CIN 1 < CIN 2/3 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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