Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms

Autor: Joe Taylor, Alison M Yeomans, Graham Packham
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Exploration of Targeted Anti-tumor Therapy, Vol 1, Iss 1, Pp 3-25 (2020)
Druh dokumentu: article
ISSN: 2692-3114
DOI: 10.37349/etat.2020.00002
Popis: Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins. Thus, targeted inhibition of mRNA translation is viewed as a promising new approach for cancer therapy. In this article we review current progress in investigating dysregulation of mRNA translation initiation in mature B-cell neoplasms, focusing on chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma. We discuss mechanisms and regulation of mRNA translation, potential pathways by which genetic alterations and the tumor microenvironment alters mRNA translation in malignant B cells, preclinical evaluation of drugs targeted against specific eukaryotic initiation factors and current progress towards clinical development. Overall, inhibition of mRNA translation initiation factors is an exciting and promising area for development of novel targeted anti-tumor drugs.
Databáze: Directory of Open Access Journals