Resveratrol attenuates inflammation through tristetraprolin expression in human hepatocytes
| Autor: | Akhi Moni; Asif Iqbal; Md Jamal Uddin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Journal of Advanced Biotechnology and Experimental Therapeutics, Vol 1, Iss 3, Pp 78-82 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2616-4760 63862476 |
| DOI: | 10.5455/jabet.2018.d14 |
| Popis: | Resveratrol (Resv), a polyphenolic compound have the anti-inflammatory and antioxidant effects. Tristetraprolin (TTP) destabilizes mRNAs of pro-inflammatory cytokines. However, it was not clear how Resv exerts anti-inflammatory effects on hepatocytes. In this study, we used human hepatoma cell line (HepG2 cells) and analyzed samples using qRT-PCR. Resv increases TTP expression in hepatocytes. Resv attenuates LPS-induced inflammation through TTP expression in hepatocytes. In TTP deficient hepatocytes, LPS failed to attenuate TNFα, iNOS, and IL-6 mRNA expression whereas TTP level was still decreased. Our results suggest that Resv may attenuate inflammation in hepatocytes through TTP induction at least in part. This novel Resv-TTP signaling pathway provides new possibilities for the treatment of inflammatory diseases in liver. [ J Adv Biotechnol Exp Ther 2018; 1(3.000): 78-82] |
| Databáze: | Directory of Open Access Journals |
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