| Autor: |
Zahra Khan, Seong-Min Hong, Jae-Wook Lee, Eun-Yi Moon, Jungmoo Huh, Keun-A Chang, Sun Yeou Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 80, Iss , Pp 104432- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2021.104432 |
| Popis: |
This study was aimed to evaluate the potential neurotrophic effect of Lycium barbarum fruit extract (LB-E) via increased neurite outgrowth and synaptic formation, and its neurotrophic and neuroprotective efficacy was also checked in vitro. LB-E exerted neurotrophic effects by regulating TrkA/ERK/CREB signaling. In nervous system, LB-E promoted neuronal survival and differentiation by increasing neurotrophic factor secretion in C6 glioma cells. Interestingly, LB-E increased the expressed levels of synaptophysin and GAP-43 in CNS cell lines. It also subsequently increased the number of ciliated cells and length of cilia in N1 hypothalamic neuronal cells induced by CNTF and displayed the enhanced dendrite length in primary cortical neurons. We investigated N-trans feruloyl tyramine (NTFT) from LB-E by LC-MS/MS, and confirmed NTFT as a biologically active ingredient showing the neurotrophic effect. These results suggested that NTFT from LB-E may be beneficial in the treatment of age-related brain diseases caused by the deficiency of neurotrophins. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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