Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort

Autor: Hiromi Tanabe, Kenichi Sakurai, Tamotsu Kato, Yohei Kawasaki, Taiji Nakano, Fumiya Yamaide, Naoko Taguchi-Atarashi, Masahiro Watanabe, Shingo Ochiai, Hiroshi Ohno, Hideoki Fukuoka, Naoki Shimojo, Chisato Mori
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: World Allergy Organization Journal, Vol 12, Iss 10, Pp - (2019)
Druh dokumentu: article
ISSN: 1939-4551
DOI: 10.1016/j.waojou.2019.100065
Popis: Background: The prenatal maternal microbiome, including the gut microbiota, has been suggested to influence the incidence of allergies in offspring. Moreover, epidermal barrier dysfunction in early infancy has been attributed to the development of subsequent allergies. We hypothesized that the prenatal microbiome may affect the gut microbiota, acting as an initial trigger to alter immune development in the foetus. The maternal microbial composition may be linked to the prevalence of dermatitis in early infancy (DEI) of the offspring, leading to subsequent allergic symptoms. Methods: This study was conducted as part of the Chiba Study of Mother and Child Health (C-MACH) birth cohort that was initiated in 2013; 434 healthy pregnant women at
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