Neonatal Hemolytic Disease Caused by Anti-e and Anti-C Antibodies Treated with Intensive Phototherapy: A Case Report
| Autor: | Gihoon Jung, Jin Kyu Kim, Sun Jun Kim, Hyun Ho Kim |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Neonatal Medicine, Vol 30, Iss 3, Pp 79-82 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2287-9412 2287-9803 |
| DOI: | 10.5385/nm.2023.30.3.79 |
| Popis: | ABO and Rh incompatibility are the leading causes of hemolytic disease of the fetus and newborn (HFDN). Due to the high antigenicity of the D antigen, hemolysis and symptoms progress rapidly. However, minor blood group incompatibility manifests varying clinical symptoms, from asymptomatic cases to neonatal jaundice and fetal hydrops. This study presents a case of HFDN in which anti-C and anti-e antibodies were identified and treated with intensive phototherapy. A full-term infant weighing 3,100 g at birth, with no complications during delivery, presented with jaundice and was admitted for intensive phototherapy. Antibody testing detected anti-C and anti-e antibodies in the neonate and the mother. The patient responded well to phototherapy, and intravenous immunoglobulin was administered. The total bilirubin levels decreased, and the infant was discharged after 5 days. At the age of 12 months, the infant exhibited normal neurodevelopment. In conclusion, neonates with HFDN, due to rare minor blood incompatibility, specifically anti-C and anti-e antibodies, can mitigate hyperbilirubinemia using phototherapy. Future research should also consider the severity of the minor blood group incompatibility. |
| Databáze: | Directory of Open Access Journals |
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