| Autor: |
Paolo E. Porporato, Valéry L. Payen, Jhudit Pérez-Escuredo, Christophe J. De Saedeleer, Pierre Danhier, Tamara Copetti, Suveera Dhup, Morgane Tardy, Thibaut Vazeille, Caroline Bouzin, Olivier Feron, Carine Michiels, Bernard Gallez, Pierre Sonveaux |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Cell Reports, Vol 8, Iss 3, Pp 754-766 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2014.06.043 |
| Popis: |
Metastatic progression of cancer is associated with poor outcome, and here we examine metabolic changes underlying this process. Although aerobic glycolysis is known to promote metastasis, we have now identified a different switch primarily affecting mitochondria. The switch involves overload of the electron transport chain (ETC) with preserved mitochondrial functions but increased mitochondrial superoxide production. It provides a metastatic advantage phenocopied by partial ETC inhibition, another situation associated with enhanced superoxide production. Both cases involved protein tyrosine kinases Src and Pyk2 as downstream effectors. Thus, two different events, ETC overload and partial ETC inhibition, promote superoxide-dependent tumor cell migration, invasion, clonogenicity, and metastasis. Consequently, specific scavenging of mitochondrial superoxide with mitoTEMPO blocked tumor cell migration and prevented spontaneous tumor metastasis in murine and human tumor models. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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