Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors

Autor: Isabela Ribeiro MADALENA, Caio Luiz Bitencourt REIS, Mirian Aiko Nakane MATSUMOTO, Maria Bernadete Sasso STUANI, Natanael Henrique Ribeiro MATTOS, Daniela Silva Barroso de OLIVEIRA, Maria Angélica Hueb de Menezes OLIVEIRA, Liliane ROSKAMP, Erika Calvano KÜCHLER, Flares BARATTO-FILHO
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Applied Oral Science, Vol 31 (2023)
Druh dokumentu: article
ISSN: 1678-7765
1678-7757
DOI: 10.1590/1678-7757-2023-0184
Popis: Abstract Background Genetic polymorphisms have been shown to influence several physiological traits, including dental and craniofacial characteristics. Understanding the clinical relevance of genetic polymorphisms in dental practice is crucial to personalize treatment plans and improve treatment outcomes. Objective to evaluate the association between dental age and genetic polymorphisms in genes encoding estrogen receptors alpha and beta (ESR1 and ESR2, respectively) in a sample of Brazilian children. Methodology This retrospective cross-sectional study was performed with children undergoing orthodontic treatment. Patients with syndromes, congenital anomalies, craniofacial deformities, under hormonal or systemic treatment, and with a previous history of facial trauma were excluded. Panoramic radiographs were used to assess dental age according to the Demirjian, Goldstein, and Tanner method. A delta [dental age-chronological age (DA-CA)] was obtained, which shows whether the patient tends to have a normal, delayed (negative values), or advanced (positive values) dental age. DNA isolated from buccal cells was used to genotype four genetic polymorphisms: rs9340799 (A>G) and rs2234693 (C>T), located in ESR1; and rs1256049 (C>T) and rs4986938 (C>T), located in ESR2. A statistical analysis was performed and values of p0.05). Genetic polymorphisms in ESR1 and ESR2 were not associated with dental age (p>0.05). Conclusion The studied genetic polymorphisms in ESR1 and ESR2 were not associated with dental age in Brazilian children.
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