Circular RNA_0003489 reflects unfavorable treatment response and shortened survival in newly diagnosed multiple myeloma patients who receive bortezomib-based induction therapy

Autor:	Senhua Song, Junjie Xie, Biao Xu, Qijie Ran
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Circular RNA_0003489 newly diagnosed multiple myeloma treatment response survival bortezomib-based induction therapy Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Hematology, Vol 29, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	16078454 1607-8454
DOI:	10.1080/16078454.2024.2399419
Popis:	Objectives Circular RNA_0003489 (Circ_0003489) promotes multiple myeloma (MM) progression and bortezomib resistance in MM cells, while its potential as a biomarker in newly diagnosed MM (NDMM) patients is unclear. Thus, this study aimed to investigate the association of circ_0003489 expression with treatment response and survival in NDMM patients who received bortezomib-based induction therapy.Methods Bone marrow (BM) specimens from 85 NDMM patients at diagnosis or before treatment and from 15 donor controls during BM examination were retrieved in this retrospective study. Circ_0003489 derived from BM plasma cells was detected by reverse transcription-quantitative polymerase chain reaction and cut by quartile and median for further analysis.Results Circ_0003489 expression was increased in NDMM patients versus donor controls (P
Databáze:	Directory of Open Access Journals
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