Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance

Autor: Chakraborty Reena, Dekkers Jack CM
Jazyk: German<br />English<br />French
Rok vydání: 2004
Předmět:
Zdroj: Genetics Selection Evolution, Vol 36, Iss 3, Pp 297-324 (2004)
Druh dokumentu: article
ISSN: 1297-9686
0999-193X
DOI: 10.1186/1297-9686-36-3-297
Popis: Abstract A method was developed to optimize simultaneous selection for a quantitative trait with a known QTL within a male and a female line to maximize crossbred performance from a two-way cross. Strategies to maximize cumulative discounted response in crossbred performance over ten generations were derived by optimizing weights in an index of a QTL and phenotype. Strategies were compared to selection on purebred phenotype. Extra responses were limited for QTL with additive and partial dominance effects, but substantial for QTL with over-dominance, for which optimal QTL selection resulted in differential selection in male and female lines to increase the frequency of heterozygotes and polygenic responses. For over-dominant QTL, maximization of crossbred performance one generation at a time resulted in similar responses as optimization across all generations and simultaneous optimal selection in a male and female line resulted in greater response than optimal selection within a single line without crossbreeding. Results show that strategic use of information on over-dominant QTL can enhance crossbred performance without crossbred testing.
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