Factors predicting pathological complete response to neoadjuvant chemotherapy in patients diagnosed with non-metastatic muscle invasive urothelial bladder cancer

Autor: Zuhat Urakçı, Senar Ebinç, Sezai Tunç, Zeynep Oruç, Mehmet Küçüköner, Muhammet Ali Kaplan, Abdurrahman Işıkdoğan
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Northwestern Medical Journal, Vol 3, Iss 3 (2023)
Druh dokumentu: article
ISSN: 2979-9538
DOI: 10.54307/NWMJ.2023.41275
Popis: Aim: In this study, we aimed to investigate the factors that may have the potential to predict pathological complete response (pCR) with platinum-based neoadjuvant chemotherapy (NAC) in non-metastatic muscle-invasive bladder cancer (MIBC). Methods: Our study included 46 patients diagnosed with non-metastatic MIBC, who applied to Dicle University Medical Oncology Clinic between 2016-2019 years and received NAC. Age, gender, ECOG performance score, tumor grade, pathological tumor (pT) stage, clinical lymph node (cN) status, localization of the primary tumor in the bladder, presence of comorbid diseases, renal failure status, hydronephrosis, and NAC regimens were analyzed. Results: Of the total 46 patients included in the study, 42 (81.3%) were male and 4 (8.7%) were female. The median age at diagnosis was 61.5 (34-77) years. In the group of patients aged
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