Characterization of a murine model of endothelial dysfunction induced by chronic intraperitoneal administration of angiotensin II

Autor: Celeste Trejo-Moreno, Enrique Jiménez-Ferrer, Gabriela Castro-Martínez, Marisol Méndez-Martínez, María Angélica Santana, Gerardo Arrellín-Rosas, José Pedraza-Chaverri, Omar Noel Medina-Campos, Beatriz Hernández-Téllez, Oscar Ramírez-Pliego, Maribel Herrera-Ruiz, Jacquelynne Cervantes-Torres, Zimri Aziel Alvarado-Ojeda, Alejandro Costet-Mejía, Gladis Fragoso, Gabriela Rosas-Salgado
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-021-00676-x
Popis: Abstract Endothelial dysfunction (ED) is a key factor for the development of cardiovascular diseases. Due to its chronic, life-threatening nature, ED only can be studied experimentally in animal models. Therefore, this work was aimed to characterize a murine model of ED induced by a daily intraperitoneal administration of angiotensin II (AGII) for 10 weeks. Oxidative stress, inflammation, vascular remodeling, hypertension, and damage to various target organs were evaluated in treated animals. The results indicated that a chronic intraperitoneal administration of AGII increases the production of systemic soluble VCAM, ROS and ICAM-1 expression, and the production of TNFα, IL1β, IL17A, IL4, TGFβ, and IL10 in the kidney, as well as blood pressure levels; it also promotes vascular remodeling and induces non-alcoholic fatty liver disease, glomerulosclerosis, and proliferative retinopathy. Therefore, the model herein proposed can be a representative model for ED; additionally, it is easy to implement, safe, rapid, and inexpensive.
Databáze: Directory of Open Access Journals
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