Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor
| Autor: | Cathriona R. Monnard, Elie-Jacques Fares, Julie Calonne, Jennifer L. Miles-Chan, Jean-Pierre Montani, Dominique Durrer, Yves Schutz, Abdul G. Dulloo |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Frontiers in Endocrinology, Vol 8 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1664-2392 42748895 |
| DOI: | 10.3389/fendo.2017.00130 |
| Popis: | BackgroundThere is increasing interest in the use of pill-sized ingestible capsule telemetric sensors for assessing core body temperature (Tc) as a potential indicator of variability in metabolic efficiency and thrifty metabolic traits. The aim of this study was to investigate the feasibility and accuracy of measuring Tc using the CorTemp® system.MethodsTc was measured over an average of 20 h in 27 human subjects, with measurements of energy expenditure made in the overnight fasted state at rest, during standardized low-intensity physical activity and after a 600 kcal mixed meal. Validation of accuracy of the capsule sensors was made ex vivo against mercury and electronic thermometers across the physiological range (35–40°C) in morning and afternoon of 2 or 3 consecutive days. Comparisons between capsule sensors and thermometers were made using Bland–Altman analysis. Systematic bias, error, and temperature drift over time were assessed.ResultsThe circadian Tc profile classically reported in free-living humans was confirmed. Significant increases in Tc (+0.2°C) were found in response to low-power cycling at 40–50 W (~3–4 METs), but no changes in Tc were detectable during low-level isometric leg press exercise ( |
| Databáze: | Directory of Open Access Journals |
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