Latent tuberculosis screening before kidney transplantation in the South of Brazil

Autor: Gisele Meinerz, Cynthia Keitel da Silva, Damaris Mikaela Balin Dorsdt, Julia Bertoni Adames, Julio Pasquali Andrade, Pedro Enrico Ventura, Alexandre de Almeida Monteiro, Alessandro Comarú Pasqualotto, Valter Duro Garcia, Elizete Keitel
Jazyk: English<br />Portuguese
Rok vydání: 2021
Předmět:
Zdroj: Brazilian Journal of Nephrology, Vol 43, Iss 4, Pp 520-529 (2021)
Druh dokumentu: article
ISSN: 2175-8239
DOI: 10.1590/2175-8239-jbn-2020-0189
Popis: Abstract Background: Tuberculosis (TB) is a prevalent infection after kidney transplantation (KT) in high-burden countries. Latent tuberculosis infection (LTBI) screening includes previous TB history, chest radiograph findings, and tuberculin test (TST) and/or interferon-gamma release assays (IGRAs) results. We aimed to compare our routine LTBI screening of KT candidates and living donors (LD) with their IGRA results, and evaluate if this would improve isoniazid (INH) treatment referral. Methods: We evaluated adult KT candidates and LD with complete routine LTBI screening and QuantiFERON-TB® Gold In-Tube (QFT) testing. Blood samples were collected from April 4th, 2014 to October 31st, 2018, with follow-up until October 31st, 2019. Results: There were 116 KT recipients, with 30% QFT-positive results. Positive QFT was associated with past TB history (p=0.007), positive TST (p
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