The State of the Art on Blood MicroRNAs in Pancreatic Ductal Adenocarcinoma

Autor: Zhuqing Gao, Wei Jiang, Shutian Zhang, Peng Li
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Analytical Cellular Pathology, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 2210-7177
2210-7185
DOI: 10.1155/2019/9419072
Popis: Despite enormous advances being made in diagnosis and therapeutic interventions, pancreatic ductal adenocarcinoma (PDAC) is still recognized as one of the most lethal malignancies. Early diagnosis and timely curative surgery can markedly improve the prognosis; hence, there is an unmet necessity to explore efficient biomarkers for patients’ benefit. Recently, blood miRNAs (miRNAs) have been reported to be a novel biomarker in human cancers. Part of it is selectively packaged by plasma exosomes released from cells via exocytosis and is highly sensitive to changes in the tumor microenvironment. Furthermore, due to less invasiveness and technical availability, miRNA-based liquid biopsy holds promise for further wide usage. Therefore, this review is aimed at presenting an update on the association between blood miRNAs and the biology of PDAC, then discussing its clinical utilization further.
Databáze: Directory of Open Access Journals
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