Clinical Features and Characteristics of Hand, Foot, and Mouth Disease Caused by Recent Coxsackievirus A6: Five Cases in Japan from 2019 to 2022

Autor:	Kyohei Naomiya, Takashi Ito, Ayumi Saito, Tsukasa Igarashi, Tetsuo Nakayama, Kazuhiko Katayama, Kenji Ishikura
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	enterovirus coxsackievirus A6 hand foot and mouth disease herpes zoster virus herpes simplex virus reverse transcription–polymerase chain reaction (RT-PCR) Other systems of medicine RZ201-999
Zdroj:	Infectious Disease Reports, Vol 16, Iss 4, Pp 587-592 (2024)
Druh dokumentu:	article
ISSN:	2036-7449
DOI:	10.3390/idr16040044
Popis:	Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by enteroviruses. Coxsackievirus A6 (CV-A6)-associated HFMD has recently emerged as a predominant disease worldwide. Here, we describe five HFMD cases caused by CV-A6 in Japan from 2019 to 2022. All clinical courses were not severe and were self-limited, and the skin exanthema with vesicles differed from that in classical HFMD. Phylogenetic analysis showed that the major epidemic strain cluster of CV-A6 was formed independently in 2011, and our latest CV-A6 strains in Japan were detected within this cluster. The five cases described in this report indicate the recent shift in the predominant and continuous disease manifestation of CV-A6-associated HFMD.
Databáze:	Directory of Open Access Journals
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