| Autor: |
Čepelak Ivana, Dodig Slavica, Dodig Daniela Čepelak |
| Jazyk: |
English<br />Croatian |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Arhiv za Higijenu Rada i Toksikologiju, Vol 71, Iss 2, Pp 99-109 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1848-6312 |
| DOI: |
10.2478/aiht-2020-71-3366 |
| Popis: |
Ferroptosis is a recently identified form of regulated cell death that differs from other known forms of cell death morphologically, biochemically, and genetically. The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity. Ferroptosis has increasingly been associated with neurodegenerative diseases, carcinogenesis, stroke, intracerebral haemorrhage, traumatic brain injury, and ischemia-reperfusion injury. It has also shown a significant therapeutic potential in the treatment of cancer and other diseases. This review summarises current knowledge about and the mechanisms that regulate ferroptosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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