BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians
| Autor: | Consuelo Borrás, Cristina Mas-Bargues, Aurora Román-Domínguez, Jorge Sanz-Ros, Lucia Gimeno-Mallench, Marta Inglés, Juan Gambini, José Viña |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 2, p 418 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1422-0067 21020418 |
| DOI: | 10.3390/ijms21020418 |
| Popis: | B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways can be both beneficial or detrimental depending on the circumstances. Thus, targeting BCL-xL would in turn be a “double-edge sword” and therefore, additional studies are needed to better comprehend this dual and apparently contradictory role of BCL-XL in longevity. |
| Databáze: | Directory of Open Access Journals |
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