The Relationship Between the Multiple Sclerosis and Endogenous Antioxidan Serum Uric Acid
| Autor: | Fatma Candan, Nihal Işık, İlknur Aydın Cantürk, Zahide Yılmaz, Reyhan Gürer, Nüket Yıldız |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Türk Nöroloji Dergisi, Vol 13, Iss 6, Pp 409-414 (2007) |
| Druh dokumentu: | article |
| ISSN: | 1301-062X 1309-2545 |
| Popis: | OBJECTIVE: Peroxynitrite (PRN) is a strong oxidant capable of damaging tissues and cells, and plays a major role in the pathogenesis of multiple sclerosis (MS). Uric acid (UA) is the naturally occuring final product of the purine metabolism in humans and the most prominent endojen antioxidant in serum. Uric acid selectively binds and inactivates the PRN. Recent studies suggested that patients with multiple sclerosis (MS) have lower levels of serum UA. To investigate the role of the endogenous antioxidant defence in MS pathogenesis, by determining the serum UA levels of the MS patients and, examining the relationships with demographic and clinical characteristics of the patients. METHODS: Serum uric acid levels were determined in 206 MS patients (151 women) all in the remission period, and in 38 age and sex matched voluntary healthy subjects, served as a control group. Of the 206 patients; 159 had the relapsing-remitting (RR) type of the disease, 37 secondary progressive (SP) and 10 primary progressive (PP). Disability as assessed by EDSS (Expanded Disability Status Scale) score. In addition, during the follow up period (12 months), relapses were observed in 45 of the 206 patients. Serum UA levels and EDSS of the patients were also determined in the relapse period before the treatment and, compared with remission period. RESULTS: In the overall MS group, serum UA levels were significantly lower than in controls (p |
| Databáze: | Directory of Open Access Journals |
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