The effects of sertraline on blood lipids, glucose, insulin and HBA1C levels: A prospective clinical trial on depressive patients

Autor: Murat Kesim, Ahmet Tiryaki, Mine Kadioglu, Efnan Muci, Nuri Ihsan Kalyoncu, Ersin Yaris
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Journal of Research in Medical Sciences, Vol 16, Iss 12, Pp 1525-1531 (2011)
Druh dokumentu: article
ISSN: 1735-1995
1735-7136
Popis: Background: In this study, we aimed to investigate the possible effects of sertraline on blood glucose and lipid levels as risk factors for cardiovascular disease in depressive patients. Methods: Eight male and twelve female depressive patients, diagnosed according to DSM-IV criteria, were included in this study. The subjects aged 19-50 years, did not smoke, and had normal body mass index (BMI), homeostasis model assessment-estimated insulin resistance (HOMA-IR) values, blood pressure, blood glucose, insulin and lipid levels. Sertraline therapy (50 mg/day) was started. Patients with diabetes mellitus, heart disease, pregnancy, and those taking other drugs were excluded from the study. Blood glucose, insulin, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride values were measured in patients before, and at the 4 th, 8th and 12th weeks after treatment with sertraline. Moreover, HbA1C levels were measured at the beginning and at the end of the treatment (at 12th weeks). Results: There were no significant differences in physical examination (blood pressure, BMI, body weight, height, waist circumference) and laboratory findings (glucose, HDL-C, LDL-C, HOMA-IR and HbA1C levels) at the 12th week after of treatment with sertraline compared to pretreatment values. However, insulin levels at the 4 th, 8th and 12th weeks significantly increased compared with pretreatment values. Likewise, triglyceride levels at the 8th and 12th weeks significantly increased compared with pretreatment values. Conclusions: Sertraline-treated patients have to be followed up for blood insulin and triglyceride levels. In addition, their treatment plan needs to be adjusted as necessary to prevent possible metabolic changes.
Databáze: Directory of Open Access Journals
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