Association between hyperglycemia at ICU admission and postoperative acute kidney injury in patients undergoing cardiac surgery: Analysis of the MIMIC-IV database

Autor: Juan Ruan, Weipeng Huang, Jun Jiang, Chang Hu, Yiming Li, Zhiyong Peng, Shuhan Cai
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Intensive Medicine, Vol 4, Iss 4, Pp 526-536 (2024)
Druh dokumentu: article
ISSN: 2667-100X
DOI: 10.1016/j.jointm.2024.04.004
Popis: Background: This study aimed to explore the correlation between hyperglycemia at intensive care unit (ICU) admission and the incidence of acute kidney injury (AKI) in patients after cardiac surgery. Methods: We conducted a retrospective cohort study, in which clinical data were extracted from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Adults (≥18 years) in the database who were admitted to the cardiovascular intensive care unit after cardiac surgery were enrolled. The primary outcome was the incidence of AKI within 7 days following ICU admission. Secondary outcomes included ICU mortality, hospital mortality, ICU length of stay, and the 28-day and 90-day mortality. Multivariable Cox regression analysis was used to assess the association between ICU-admission hyperglycemia and AKI incidence within 7 days of ICU admission. Different adjustment strategies were used to adjust for potential confounders. Patients were divided into three groups according to their highest blood glucose levels recorded within 24 h of ICU admission: no hyperglycemia (
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