| Autor: |
Edemariam Tsega, John Horton, Erik Nordenfelt, B-J Hansson, Belachew Tafesse, Gizachew Wolde-Hawariat, Johan Lindberg |
| Jazyk: |
angličtina |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Canadian Journal of Gastroenterology, Vol 12, Iss 1, Pp 57-60 (1998) |
| Druh dokumentu: |
article |
| ISSN: |
0835-7900 |
| DOI: |
10.1155/1998/213028 |
| Popis: |
It was hypothesized that, following effective initial vaccination, a booster dose of hepatitis B vaccine will not be necessary in areas of hyperendemicity for hepatitis B virus (HBV) infection. A total of 314 Ethiopian children, ranging from two to 14 years old, were alternatively vaccinated with 10 and 20 µg hepatitis B vaccine doses, using the initial, one- and six-month schedule. Five years later, 210 of the vaccinees were retested for anti-HBV surface antibody titres. Both 10 and 20 µg doses of hepatitis B rDNA yeast vaccine were equally immunogenic and protective against HBV infection for at least five years despite marked reduction of mean antibody levels and geometric mean titres, with 11% of the vaccinees showing antibodies below the protective level. For firm further recommendations a longer follow-up period of vaccinees is suggested. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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