| Autor: |
Naidu Kavitha, Thennarasu Padmini Karunya, Shankar Kanchana, Kumar Mohan, Ramachandiran Sivaramakrishnan, Selvaraj Uthra, Kalimuthu Kapilan, Dinakarkumar Yuvaraj, Muthuvel Arumugam |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 5, Iss 12, Pp e02916- (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2019.e02916 |
| Popis: |
Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 ± 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirmations of ALG were studied through FTIR, XRD and SEM analysis. Formulation of ALG with collagen (COL) as a wound healing microfilm showed potential anti-inflammatory properties (81.3 ± 1.77%) and sustained drug release. Likewise, the ALG microbead encapsulated with an anticancer drug, Tamoxifen indicated an in vitro sustained release in the range of 62 ± 0.70% - 91 ± 0.56%. The overall swelling behavior of both the hydrogels, microfilm and microbead provides new opportunities for development of natural ALG in this therapeutic era. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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