The Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women

Autor: Elias Tsougos, Emmanouil Korakas, Vasileios Kolovos, Georgia-Angeliki Koliou, Georgios Papageorgiou, Aikaterini Kountouri, Konstantinos Balampanis, Loukia Pliouta, Savvas Loizos, Nikolaos Karamichalakis, Elias Gatos, Ignatios Ikonomidis, Paraskevi Kazakou, Athanasios Raptis, Vaia Lambadiari
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Medicina, Vol 57, Iss 11, p 1154 (2021)
Druh dokumentu: article
ISSN: 57111154
1648-9144
1010-660X
DOI: 10.3390/medicina57111154
Popis: Background and Objectives: The effects of gender differences on cardiac parameters have been well-established. In this study, we aimed to evaluate the possible associations of plasma levels of different sex hormones with premature atrial or ventricular contractions in premenopausal women. Materials and Methods: We conducted a prospective study which included women in late reproductive age who presented with palpitations during an eight-month period. A 12-lead electrocardiography, a transthoracic echocardiogram, blood samples, and 24-hour rhythm Holter were conducted on the third day of the menstrual cycle. Results Overall, 93 healthy premenopausal women with a median age of 42 years were enrolled. QTc interval was within normal limits in all patients. The 24 h range of premature atrial contractions (PACs) and premature ventricular contractions (PVCs) was 0–6450 and was 0–21,230, respectively. The median number of PVCs was 540 and the median number of PACs was 212, respectively. In total, 51 patients (54.8%) had a frequency of PVCs > 500/24 h and 37 patients (39.8%) had a frequency of PACs > 500/24 h, respectively. No statistically significant association was shown between any hormone and the frequency of PACs. Regarding PVCs, patients with a PVCs frequency > 500/24 h had higher estradiol levels compared to patients with PVCs less than 500/24 h (median 60 pg/mL versus 42 pg/mL, p = 0.02, OR: 1.01). No association was found between PVCs and other hormones. Conclusions: In premenopausal healthy women, higher estradiol levels are independently associated with increased PVCs. This suggests that estradiol in late reproductive stages may exert proarrhythmic effects.
Databáze: Directory of Open Access Journals
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