Apolipoprotein E polymorphism in a Romanian population

Autor:	Diaconu Rodica, Dumitrașcu Andreea-Ramona, Liehn Elisa, Pîrvu Andrei, Ioana Mihai, Alexandru Dragoș, Țieranu Eugen, Bălșeanu Tudor-Adrian, Donoiu Ionuț
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	apolipoprotein e genotyping allele variants cardiovascular risk apolipoproteină e genotipare variante de alele risc cardiovascular Internal medicine RC31-1245
Zdroj:	Romanian Journal of Cardiology, Vol 33, Iss 1, Pp 19-24 (2023)
Druh dokumentu:	article
ISSN:	2734-6382
DOI:	10.2478/rjc-2022-0031
Popis:	Background: Apolipoprotein E (ApoE) is a ubiquitous protein involved in maintaining cholesterol homeostasis and lipoprotein clearance from circulation. It is coded by three alleles (ε2, ε3, ε4) with six genotypes (ε3/ε3, ε3/ε4, ε2/ε3, ε4/ε4, ε2/ε4, and ε2/ε2). Several studies have shown a relationship between ApoE-specific isoforms and different diseases. There are few data about the prevalence of ApoE polymorphism in the Romanian population. We aimed to assess the prevalence of Apolipoprotein E alleles in a healthy population from Romania and compare it with the data found in other countries of Europe.
Databáze:	Directory of Open Access Journals
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