Tumor suppression by control of matrix metalloproteinase recycling

Autor: Marte Sneeggen, Kay O. Schink, Harald Stenmark
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 6, Iss 6 (2019)
Druh dokumentu: article
ISSN: 2372-3556
23723556
DOI: 10.1080/23723556.2019.1646606
Popis: Secretion of matrix metalloproteinases (MMPs) enables cancer cells to degrade extracellular matrix, thus promoting tumor invasion and metastasis. We have recently found that the endosomal protein WDFY2 serves as a gatekeeper for MMP recycling from endosomes and that deletion of WDFY2, which is frequently lost in metastatic cancers, causes increased matrix degradation and cell invasion.
Databáze: Directory of Open Access Journals
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