Administration of combined venetoclax and azacitidine in a patient with acute myeloid leukemia and multiple comorbidities undergoing dialysis: A case report

Autor: Yuina Akagi, Yusuke Yamashita, Hideki Kosako, Yoshiaki Furuya, Hiroki Hosoi, Toshiki Mushino, Shogo Murata, Akinori Nishikawa, Shinobu Tamura, Taisei Nakao, Takashi Sonoki
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: eJHaem, Vol 4, Iss 3, Pp 841-843 (2023)
Druh dokumentu: article
ISSN: 2688-6146
DOI: 10.1002/jha2.732
Popis: Abstract Patients with acute myeloid leukemia (AML) who have comorbidities have limited treatment options, thereby resulting in poor prognosis. Venetoclax, a specific B‐cell lymphoma‐2 inhibitor, has recently been approved for AML in combination with hypomethylating agents; however, only one report has described its use in patients undergoing dialysis. Herein, we report the effectiveness of combined venetoclax and azacitidine in a 73‐year‐old man with AML undergoing dialysis and who was ineligible for standard therapies. The safety of venetoclax and azacitidine in patients undergoing dialysis has been reported, and their combination may be a feasible option for patients with AML undergoing dialysis.
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