Relationship between non-alcoholic fatty liver and progressive fibrosis and serum 25-hydroxy vitamin D in patients with type 2 diabetes mellitus

Autor: Jing-Xian Fang, Yu Han, Jian Meng, Hui-Ming Zou, Xue Hu, Yue-Xia Han, Fang Huang, Qing Gu, Sui-Jun Wang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Endocrine Disorders, Vol 24, Iss 1, Pp 1-6 (2024)
Druh dokumentu: article
ISSN: 1472-6823
DOI: 10.1186/s12902-024-01640-2
Popis: Abstract Objective We aimed to analyze the relationship between non-alcoholic fatty liver and progressive fibrosis and serum 25-hydroxy vitamin D (25(OH)D) in patients with type 2 diabetes mellitus. Methods A total of 184 patients with T2DM who were hospitalized in the Department of Endocrinology of the ShiDong Clinical Hospital between January 2023 and June 2023 were selected. We compared review of anthropometric, biochemical, and inflammatory parameters and non-invasive scores between groups defined by ultrasound NAFLD severity grades.We determine the correlation between 25(OH)D and FLI and FIB-4 scores, respectively. Results Statistically significant differences were seen between BMI, WC, C-peptide levels, FPG, ALT, serum 25(OH)D, TC, HDL, lumbar spine bone density, FLI, and FIB-4 in different degrees of NAFLD. Multivariate logistic regression analysis showed that 25(OH)D (OR = 1.26, p = 0.001), age (OR = 0.93, P
Databáze: Directory of Open Access Journals
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