Scanning photoacoustic imaging of submucosal gastric tumor based on a long focused transducer in phantom and in vitro experiments

Autor: Hua-Qin Wu, Hao-Yu Wang, Wen-Ming Xie, Shu-Lian Wu, Zhi-Fang Li, Xiao-Man Zhang, Hui Li
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Innovative Optical Health Sciences, Vol 12, Iss 3, Pp 1950011-1-1950011-12 (2019)
Druh dokumentu: article
ISSN: 1793-5458
1793-7205
17935458
DOI: 10.1142/S1793545819500111
Popis: Photoacoustic imaging, which can provide the maximum intensity contrast in tissue depth imaging without ionizing radiation, will be a promising imaging trend for tumor detection. In this paper, a column diffusion fiber was employed to carry a pulsed laser for irradiating stomach directly through esophagus based on the characteristics of gastric tissue structure. A long focused ultrasonic transducer was placed outside the body to detect photoacoustic signals of gastric tissue. Phantom and in vitro experiments of submucosal gastric tumors were carried out to check the sensitivity of scanning photoacoustic tomography system, including the lateral and longitudinal resolution of the system, sensitivity of different absorption coefficient in imaging, capability of transversal detection, and probability of longitudinal detection. The results demonstrate that our innovative technique can improve the parameters of imaging. The lateral resolution reaches 2.09mm. Then a depth of 5.5mm with a longitudinal accuracy of 0.36mm below gastric mucosa of early gastric cancer (EGC) has been achieved. In addition, the optimal absorption coefficient differences among absorbers of system are 3.3–3.9 times. Results indicate that our photoacoustic imaging (PAI) system, is based on a long focusing transducer, can provide a potential application for detecting submucosal EGC without obvious symptoms.
Databáze: Directory of Open Access Journals
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