| Autor: |
Hisaya Kato, Yoshiro Maezawa, Yasuo Ouchi, Naoya Takayama, Masamitsu Sone, Kanako Sone, Aki Takada-Watanabe, Kyoko Tsujimura, Masaya Koshizaka, Sayaka Nagasawa, Hisako Saitoh, Manami Ohtaka, Mahito Nakanishi, Hidetoshi Tahara, Akira Shimamoto, Atsushi Iwama, Koji Eto, Koutaro Yokote |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Stem Cell Research, Vol 53, Iss , Pp 102360- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2021.102360 |
| Popis: |
Adult progeria Werner syndrome (WS), a rare autosomal recessive disorder, is characterized by accelerated aging symptoms after puberty. The causative gene, WRN, is a member of the RecQ DNA helicase family and is predominantly involved in DNA replication, repair, and telomere maintenance. Here, we report the generation of iPS cells from a patient with WS and correction of the WRN gene by the CRISPR/Cas9-mediated method. These iPSC lines would be a valuable resource for deciphering the pathogenesis of WS. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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