SIMETRIA MOLECULAR E REAçõES DE DESSIMETRIZAçãO EM SíNTESE ORGâNICA

Autor:	Bruno Matos Paz, Emilio C. de Lucca Júnior, Ronaldo A. Pilli
Jazyk:	English<br />Spanish; Castilian<br />Portuguese
Rok vydání:	2021
Předmět:	molecular symmetry desymmetrization pattern recognition pseudo C2-symmetry hidden symmetry total synthesis Chemistry QD1-999
Zdroj:	Química Nova, Vol 44, Iss 8, Pp 1045-1077 (2021)
Druh dokumentu:	article
ISSN:	1678-7064 0100-4042
DOI:	10.21577/0100-4042.20170760
Popis:	MOLECULAR SYMMETRY AND DESYMMETRIZATION REACTIONS IN ORGANIC SYNTHESIS. Molecular Symmetry has found several applications in Organic Chemistry. The aim of this article is to showcase its relevance as a tool for synthetic planning. Natural Products and synthetic compounds with pharmaceutical applications were selected to highlight desymmetrization reactions that make use of organocatalysis, biocatalysis or by transition metals. The recognition of structural patterns in retrosynthetic analysis is discussed for compounds that exhibit explicit or hidden symmetry. Limitations of the aforementioned strategies are also described, as well as the untapped potential, challenges and frontiers yet to be explored regarding these concepts.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/62835d882920435e873a453b15f2a8a5 Zobrazit plný text záznamu View record in DOAJ