Chemical Constituents from the Whole Plant of Cuscuta reflexa

Autor: Tin Thu Thu Aung, Meng-Yuan Xia, Pyae Phyo Hein, Rong Tang, Dong-Dong Zhang, Jun Yang, Xue-Fei Yang, Dong-Bao Hu, Yue-Hu Wang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Natural Products and Bioprospecting, Vol 10, Iss 5, Pp 337-344 (2020)
Druh dokumentu: article
ISSN: 2192-2195
2192-2209
DOI: 10.1007/s13659-020-00265-x
Popis: Abstract Two new 2H-pyran-2-one glucosides, cuscutarosides A (1) and B (2), and one new steroidal glucoside, 7β-methoxy-β-sitosterol 3-O-β-glucopyranoside (3), together with 12 known compounds (4–15) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside (3) showed weak PPL inhibitory activity. Cuscutaroside A (1), its acetylated derivative (1a), and scrophenoside B (8) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA. Graphic Abstract
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