Urinary neutrophil gelatinase-associated lipocalin is associated with preeclampsia in a cohort of Turkish women

Autor:	Semra Yuksel, Sefik Eser Ozyurek, Deniz Kanber Acar, Cagdas Ozdemir, Sebile Guler, Huseyin Kiyak, Ali Gedikbasi
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	preeclampsia neutrophil gelatinase associated lipocalin severe preeclampsia preeclampsia diagnosis Gynecology and obstetrics RG1-991
Zdroj:	Hypertension in Pregnancy, Vol 38, Iss 3, Pp 157-162 (2019)
Druh dokumentu:	article
ISSN:	1064-1955 1525-6065 10641955
DOI:	10.1080/10641955.2019.1621887
Popis:	Purpose: We investigated the optimal cut-off level for urinary neutrophil gelatinase-associated lipocalin (NGAL) in preeclamptic patients to confirm the diagnosis. Methods: Urinary NGAL concentrations were measured by specific enzyme-linked immunosorbent assay (ELISA). Results: Patients with preeclampsia had significantly higher urinary NGAL concentrations than controls (mean: 387 ng/ml vs. 188 ng/ml, respectively; P< 0.001). Using a cutoff value 252 ng/ml for urinary NGAL to confirm diagnosis of preeclampsia, sensitivity, and specificity were 92% and 91%, respectively. Conclusion: Urinary NGAL concentrations were significantly elevated in women with preeclampsia versus normotensive controls.
Databáze:	Directory of Open Access Journals
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